Endocrine Abstracts

Background: Ectopic ACTH syndrome (EAS) is rare and published series are scarce.Aim: To increase the understanding of EAS we describe 31 consecutive cases in years 1997–2016.Results: Of the 31 patients, 65% (20/31) were women and 35% (11/31) men. Median follow-up was 23 months (0–217). Median age at diagnosis was 62 years (21–78), with peak incidences in age groups 30–39 and 60–69 years. Most patients prese...

Background: The best lateralization method to ascertain cure after surgery in unilateral primary aldosteronism (PA) is debated. Risk of persistent of PA in those with non-classical adrenal histopathology remains poorly characterized.Objective: We examined the value of anatomical compared with functional subtyping and the significance of immunohistochemical analysis of CYP11B1 and CYP11B2 for the outcome and histopathological diagnosis of primary aldoster...

Background: The cure of unilateral primary aldosteronism (PA) after adrenalectomy can result in complete, partial or absent biochemical and clinical improvement1. Histological findings from HE samples are of little assistance in determining if adenoma or hyperplastic adrenal tissue is hormonally overactive. Our aim in the present study was to compare immunohistochemical (IHC) CYP11B1 and CYP11B2 staining in adrenal slices to histological diagnosis based on H&E s...

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT). Distinguishing PC from other tumours underlying PHPT can be difficult and sometimes malignant diagnosis can be made only after recurrence of the disease. Atypical parathyroid adenomas (APA) have similar histological features as PC but lack signs of invasive growth. The expression of somatostatin receptors (SSTR) 1–5 in parathyroid tumours, commonly expressed in other neuroendocri...

Introduction and design: Parathyroid carcinoma (PC) is a rare endocrine malignancy and the diagnosis is difficult. As the incidence seems to be increasing, we examined all cases diagnosed in our country during years 2000–2011 and compared the results to those of atypical parathyroid (AA; n=28) and parathyroid adenomas (A; n=72). All tissue specimens were re-examined.Results: In 2000–2011, 32 patients were diagnosed with PC in ...